null
SMILES CN1C2=NC3(CCCC3)CN2c2nc(Cc3ccc(cc3)-c3ccccc3)n(Cc3ccccc3)c2C1=O
InChI Key InChIKey=RRRMTTFOHGYQIH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50059026
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 3 (PDE3) purified from bovine heartMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Evaluated for inhibitory activity against Phosphodiesterase 5 (PDE5) purified from bovine lungMore data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Bos taurus)
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant bovine adrenal cortex Phosphodiesterase 2 (PDE2)More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Dart Neuroscience LLC
Curated by ChEMBL
Dart Neuroscience LLC
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibitory activity against recombinant human calpain 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience LLC
Curated by ChEMBL
Dart Neuroscience LLC
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience LLC
Curated by ChEMBL
Dart Neuroscience LLC
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Banasthali University
Curated by ChEMBL
Banasthali University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair