null

SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc(OCC#N)cc3)n2)c1

InChI Key InChIKey=GKHSBHLDGUQELD-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068779   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 430nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7GKQUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47S6WUS Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49SFKPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)copy SMILEScopy InChI
Affinity DataEC50:  210nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49SFKPubMed