null
SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 50073587
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Competitive inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Competitive binding to PLK4 (unknown origin) by double reciprocal plot analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using DBF as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of AURKA (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Inhibition of PLK4 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 510nMAssay Description:Inhibition of AURKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 117nMAssay Description:Inhibition of TIE2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 84nMAssay Description:Inhibition of TRKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 88nMAssay Description:Inhibition of TRKB (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of TIE2 (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of TRKA (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of TRKB (unknown origin) by FRET analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PLK-3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PLK-2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PLK-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 88nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 84nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 117nMAssay Description:Inhibition of TIE2/TEK (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataEC50: 1.10E+3nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 102nMAssay Description:Inhibition of AURKB (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 510nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataIC50: 550nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataIC50: 550nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
In DepthDetails
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 940nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair