null
SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccncc21
InChI Key InChIKey=NCPRCNJIGPDNGS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50092339
TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 241nM ΔG°: -9.02kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 366nM ΔG°: -8.77kcal/mole IC50: 1.35E+3nMpH: 7.5 T: 2°CAssay Description:The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 498nM ΔG°: -8.59kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 650nM ΔG°: -8.43kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 730nM ΔG°: -8.37kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Affinity DataKi: 824nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 824nM ΔG°: -8.29kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 850nM ΔG°: -8.28kcal/mole IC50: 2.90E+3nMpH: 7.5 T: 2°CAssay Description:The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th...More data for this Ligand-Target Pair
Affinity DataKi: 1.64E+3nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataKi: 1.64E+3nM ΔG°: -7.89kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Affinity DataIC50: 2.69E+3nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD2 (333 to 460 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by f...More data for this Ligand-Target Pair
Affinity DataIC50: 4.59E+3nMAssay Description:Displacement of FAM-labeled ZBA248 from BRD4 BD1 (44 to 168 amino acid residues) (unknown origin) expressed in Rosetta2 DE3 cells after 30 mins by fl...More data for this Ligand-Target Pair