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SMILES O=C(NC1CCN(C1)C#N)OCc1ccccc1

InChI Key InChIKey=YRVGOKKZUPVDNC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50095491   

TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using bone resorption assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 7.0Assay Description:Effect of 10 mM of GSH on the inhibitory activity against Cathepsin K, at pH 7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 7.0Assay Description:Inhibition of Cathepsin K at pH 7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 5.5Assay Description:Inhibition of Cathepsin K at pH 5.5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibitory activity tested against Human Cathepsin L using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using gelatinase assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory activity tested against Human Cathepsin B using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory constant of the compound against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 90nMpH: 5.5Assay Description:Effect of 10 mM of GSH on the inhibitory activity of compound against Cathepsin K, at pH 5.5More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095491((1-Cyano-pyrrolidin-3-yl)-carbamic acid benzyl est...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1J4RPubMed