null

SMILES O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5C2)ccc4C#N)cc13

InChI Key InChIKey=NLKNPWNNYCYNKB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50101929   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 301nMAssay Description:Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]GGPP into biotinylated peptide corresponding to the C-terminus of human Ki...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WM1CTKPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 0.290nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured Ha-ras transformed RAT1 cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WM1CTKPubMed
TargetGTPase KRas(Homo sapiens (Human))
Universite£ de Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Ki-RasMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9XDVPubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9CVXPubMed
TargetDnaJ homolog subfamily A member 1(Homo sapiens (Human))
Universite£ de Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataEC50:  2nMAssay Description:Inhibition of HDJ2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9XDVPubMed
TargetRas-related protein Rap-1A(Homo sapiens (Human))
Universite£ de Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Rap1aMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9XDVPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WM1CTKPubMed