null
SMILES COc1ncc(-c2ccc3c(Nc4cc(Oc5cc(F)cc(F)c5)cc(c4)C(O)=O)c(cnc3c2)S(=O)(=O)NC2CC2)c(OC)n1
InChI Key InChIKey=RZBCPMYJIARMGV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50103568
Affinity DataKi: 4.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
National Cancer Institute-CRO
Curated by ChEMBL
National Cancer Institute-CRO
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Competitive inhibition of human LDH1 in presence of NADHMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Competitive inhibition of human LDH5 in presence of NADHMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
National Cancer Institute-CRO
Curated by ChEMBL
National Cancer Institute-CRO
Curated by ChEMBL
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human erythrocytes LDHB using sodium pyruvate as substrate after 5 mins in presence of NAPDH by diaphorase/resazurin based fluorescence...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center for Advancing Translational Sciences
Curated by ChEMBL
National Center for Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of wild type IDH1 (unknown origin) using isocitrate as substrate preincubated for 30 mins followed by substrate addition in presence of NA...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Competitive inhibition of recombinant human LDHA in the presence of NADH by resazurin dye reduction methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of LDH in human A673 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughput fl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of LDH in human MIAPaCa2 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughpu...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
Affinity DataKd: 1.70nMAssay Description:Binding affinity to human His-tagged LDHA in absence of NADH by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.18E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 59nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair