null

SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C

InChI Key InChIKey=XKEOGEXDEKIDNA-NVMNQCDNSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50107112   

TargetProtein kinase C delta type(Mus musculus)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.15nMAssay Description:Displacement of [3H]PDBu from mouse wild type C1b domain of PKCdelta expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.16nM ΔG°:  -11.9kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9NQ6PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M07G5PubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Binding affinity for isolated C1b domain of protein kinase C-deltaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8SMXPubMed
TargetProtein kinase C delta type(Mus musculus)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.21nMAssay Description:Binding affinity to mouse wildtype PKCdelta C1a expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute at Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Binding affinity for Protein kinase C alpha C1a or C1b domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5PJWPubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute at Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMpH: 7.4Assay Description:Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M07G5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute at Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]PDBu from recombinant PKC alpha in presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2TQ1PubMed
TargetProtein kinase C alpha type(MOUSE)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]PDBu from mouse recombinant PKCalpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute at Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8R5PPubMed
TargetProtein kinase C delta type(Mus musculus)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  44.8nMAssay Description:Displacement of [3H]PDBu from mouse PKCdelta C1b Q27E mutant expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute at Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  402nM ΔG°:  -8.51kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9NQ6PubMed
TargetProtein kinase C delta type(Mus musculus)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  476nMAssay Description:Binding affinity to mouse PKC delta C1a Q27E mutant expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5TQ5PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.03E+3nM ΔG°:  -7.97kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9NQ6PubMed
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  1.07E+3nM ΔG°:  -7.95kcal/molepH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9NQ6PubMed