null

SMILES CC(C)n1c(C)c(C(=O)NCc2c(C)cc(C)nc2O)c2ccccc12

InChI Key InChIKey=FIRTTWLRGQQVTR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50110363   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Constellation Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50110363(CHEMBL3605450)copy SMILEScopy InChI
Affinity DataIC50: 159nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q24205PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Constellation Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50110363(CHEMBL3605450)copy SMILEScopy InChI
Affinity DataIC50: 512nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q24205PubMed