null

SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1

InChI Key InChIKey=IKUFKDGKRLMXEX-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50111385   

TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataEC50:  340nMAssay Description:Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1ZN6PubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of RSK2 (unknown origin) assessed as reduction in YB1 transmembrane phosphorylationMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))TBA
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of full length recombinant GST-tagged human RSK3 expressed in insect cell using biotin-labelled AGAGRSRHSSYPAGT-OH as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44DCPubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of full length recombinant His-tagged human RSK1 expressed in baculovirus expression system using biotin-labelled AGAGRSRHSSYPAGT-OH as su...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44DCPubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of full length recombinant His-tagged human RSK2 expressed in baculovirus expression system using biotin-labelled AGAGRSRHSSYPAGT-OH as su...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111385(CHEMBL3604793)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of RSK2 (unknown origin)More data for this Ligand-Target Pair