null

SMILES COc1cc(NC(=O)\C=C\CN(C)C)cc2c(Nc3cccc(Br)c3)c(cnc12)C#N

InChI Key InChIKey=MPNMKIMGGUGYMJ-VMPITWQZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50122561   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2086532PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.88E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4505PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.88E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BJH
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 9.35E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GXNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561((E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-p...)copy SMILEScopy InChI
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed