null

SMILES CC#CC(=O)Nc1ccc2ncc(C#N)c(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=PBDJWRUCRSLDEM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50122573   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 940nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ12TSPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of peptide substrate phosphorylation by epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G161DCPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 940nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4505PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 9.40E+5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BJH
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 3.87E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 933nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GXNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 259nMAssay Description:Inhibition of peptide substrate phosphorylation by epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G161DCPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122573(But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-...)copy SMILEScopy InChI
Affinity DataIC50: 940nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed