null

SMILES COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\C(C)N(C)C

InChI Key InChIKey=LQJFAOUCESCUCC-VMPITWQZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50122587   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122587((E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 5.22E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4505PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122587((E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+4nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122587((E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 5.22E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ8BJH
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122587((E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GXNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122587((E)-4-Dimethylamino-pent-2-enoic acid [4-(3-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 5.22E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6M3HPubMed