null

SMILES COc1cccc2nc(nc(NN3C(=O)C=C(C)C3=O)c12)-c1cccs1

InChI Key InChIKey=GZGLPBNOIFLLRE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50135482   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474F5DPubMed
TargetTranscription factor Jun(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2222WDTPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of IKKbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2H1KPubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataEC50:  380nMAssay Description:Potentiation of TNFalpha-induced NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4H8ZPubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataEC50:  1.60E+3nMAssay Description:Induction of NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4H8ZPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 618nMAssay Description:Inhibition of wild type FLT3 (unknown origin) expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z18W7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55PD3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of IKK-beta by tome resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CVVPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z18W7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Arromax Pharmatech Co. Ltd.

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of IKKbeta kinase (unknown origin) by Lance ULight systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4X94PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
UCB

Curated by ChEMBL
LigandPNGBDBM50135482(1-(5-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55PD3PubMed