null

SMILES Oc1c2C3CCC(C3)c2c(O)n1-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=DIVQSPFDCRTNLF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50158073   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataKi:  360nMAssay Description:Displacement of [3H]DHT from human androgen receptor in MDA453 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GGTPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of [3H]-DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataKi:  1.62E+3nMAssay Description:Inhibition of [3H]-DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 152nMAssay Description:Antagonist activity at human androgen receptor in MDA453 cells by alkaline phosphatase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5GGTPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 317nMAssay Description:Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 317nMAssay Description:Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 205nMAssay Description:Inhibition of L701H/T877A mutant androgen receptor of human prostate cancer MDAMB-PCa2b cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158073((2R,6S)-4-[3-(trifluoromethyl)phenyl]-4-azatricycl...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ29GJPubMed