null
SMILES COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12
InChI Key InChIKey=RBUYFHLQNPJMQM-UHFFFAOYSA-N
PDB links: 3 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50183448
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 0.75nMAssay Description:Binding affinity to human BRD9 isoform 1 by BROMOScan analysisMore data for this Ligand-Target Pair
3D Structure (crystal)In DepthDetails
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 117nMAssay Description:Inhibition of human N-terminal GST-tagged BRD7 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScreen ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD2-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD2 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of ACVR1 (unknown origin)More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
TargetActivin receptor type-2B(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ACVR2B (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Mus musculus)
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataEC50: 275nMAssay Description:Inhibition of BRD9 in mouse RN2 cells assessed as decrease in cell proliferation by cell titer glow assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes in presence of NADPH using amodiaquine as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes in presence of NADPH using diclofenac as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes in presence of NADPH using mephenytoin as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes in presence of NADPH using midazolam as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes in presence of NADPH using dextromethorphan as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 8.80nMAssay Description:Binding affinity to human CECR2 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by BROMOScan analysisMore data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 187nMAssay Description:Binding affinity to human CECR2 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BRD4-BD1 by alpha assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD4 isoform long, bromodomain 1 by BROMOScan analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to human BRD4-BD1 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataIC50: 117nMAssay Description:Inhibition of human BRD7 measured after mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 0.300nMAssay Description:Binding affinity to human BRD7 by BROMOScan analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by SYPRO orange dye based differential scanning fluorimetryMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 9.40nMAssay Description:Binding affinity to recombinant human His-tagged BRD9 (134 to 239 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 121nMAssay Description:Binding affinity to recombinant human His-tagged BRD7 (129 to 250 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 0.316nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 0.794nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Boehringer Ingelheim RCV GmbH& Co KG
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding affinity to human BRD9 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair