null

SMILES CCOc1cc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2cc1NC(=O)\C=C\CN1C[C@H](C)N[C@H](C)C1

InChI Key InChIKey=AQEJOYTVPDGMEW-RRSRKQOQSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50191643   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50191643(CHEMBL3941823)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Irreversible inhibition of GST-tagged ERBB1 (unknown origin) (Met-668 to Ala-1211 residues) expressed in baculovirus infected Sf9 insect cells assess...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VB3PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50191643(CHEMBL3941823)copy SMILEScopy InChI
Affinity DataIC50: 6.94E+3nMAssay Description:Irreversible inhibition of human recombinant GST-tagged JAK3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in polyglutamic...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VB3PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50191643(CHEMBL3941823)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Irreversible inhibition of GST-tagged ERBB2 (unknown origin) (Ile-675 to Val-1256 residues) expressed in baculovirus infected Sf9 insect cells assess...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VB3PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50191643(CHEMBL3941823)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Irreversible inhibition of full length human ERBB1 autophosphorylation transfected in EGF-stimulated mouse NIH/3T3 cells incubated for 2 hrs followed...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VB3PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50191643(CHEMBL3941823)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3VB3PubMed