null
SMILES [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc3C[C@@H](CCCc3c2OC)N2CCN(C)CC2)ncc1Cl)C(N)=O
InChI Key InChIKey=FLTLUXCGVBUQLQ-TZLNSBNCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50193814
TargetCytochrome P450 1A2(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 508nMAssay Description:Inhibition of recombinant human INSR expressed in baculovirus using ATP as substrate after 15 mins by TRF assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone/midazolam as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Teva Branded Pharmaceutical Products R&D
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human FAK expressed in baculovirus after 30 mins using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate by TRF assayMore data for this Ligand-Target Pair