null
SMILES Cl.Cc1nnc(C)n1-c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CC[C@@H](O)C2)c(F)c1
InChI Key InChIKey=MDJADLPQDRFYIJ-SIVZDDAJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50196789
TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of rat NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Homo sapiens (Human))
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NHE1 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 5(Homo sapiens (Human))
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Affinity DataIC50: 291nMAssay Description:Inhibition of human NHE5 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP2C9 in pooled human hepatic microsomes using diclofenac substrate in presence of NADPHMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger isoform 3(Sus scrofa)
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of pig NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Sanofi-Aventis Deutschland GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NHE2 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair