null
SMILES CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O
InChI Key InChIKey=MPDGHEJMBKOTSU-YKLVYJNSSA-N
PDB links: 3 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 50233538
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
KU Leuven
Curated by ChEMBL
KU Leuven
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plotMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
KU Leuven
Curated by ChEMBL
KU Leuven
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-Universit£t Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-Universit£t Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther-Universit£t Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-Universit£t Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellm...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse 11beta-HSD1 overexpressed in microsomal fraction of HEK293 cells assessed as formation of [3H]-cortisol from [3H]-cortisone by sc...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PTP1B (unknown origin) by pNPP assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TCPTP (unknown origin) by pNPP assayMore data for this Ligand-Target Pair
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Dalian Institute of Chemical Physics
Curated by ChEMBL
Dalian Institute of Chemical Physics
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CE1 in human liver microsomes using 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
Affinity DataIC50: 6.93E+4nMAssay Description:Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of 11beta-HSD1 in rat liver assessed as cortisone levelMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Rattus norvegicus)
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of rat renal 11beta-HSD2 in rat liver assessed as inhibition of cortisone productionMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 778nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-3H]-cortisone to cortisol by scintillation count...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of recombinant SHP2More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.54E+4nMAssay Description:Inhibition of recombinant SHP1More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 4.58E+4nMAssay Description:Inhibition of recombinant PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant HePTPMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 778nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-[3H]cortisone to cortisol after 10 mins by scint...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of rat hepatic 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Rattus norvegicus)
Vienna University of Technology
Curated by ChEMBL
Vienna University of Technology
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of rat renal 11beta-HSD2More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Gifu Pharmaceutical University
Curated by ChEMBL
Gifu Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.80E+5nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as p...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 11.8nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 10.6nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of full-length mouse 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 1 hr by scintillation prox...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of full-length human 11beta-HSD1 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox...More data for this Ligand-Target Pair
TargetPancreatic alpha-amylase(Sus scrofa (Pig))
School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China.
Curated by ChEMBL
School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China.
Curated by ChEMBL
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of porcine pancreatic alpha-amylase using starch as substrate preincubated for 15 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Pin1 (unknown origin) assessed as reduction in peptidyl-prolyl isomerase activity incubated for 30 mins using Suc-Ala-Glu-cis-Pro-Phe-4...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Osaka University
Curated by ChEMBL
Osaka University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Osaka University
Curated by ChEMBL
Osaka University
Curated by ChEMBL
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Osaka University
Curated by ChEMBL
Osaka University
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as su...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Osaka University
Curated by ChEMBL
Osaka University
Curated by ChEMBL
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as su...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Institute of Materia Medica
Curated by ChEMBL
Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of mouse microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol usi...More data for this Ligand-Target Pair
TargetEgl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Universit£ del Piemonte Orientale
Curated by ChEMBL
Universit£ del Piemonte Orientale
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...More data for this Ligand-Target Pair
TargetEgl nine homolog 1/Prolyl hydroxylase EGLN2/Prolyl hydroxylase EGLN3/Transmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Universit£ del Piemonte Orientale
Curated by ChEMBL
Universit£ del Piemonte Orientale
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha aft...More data for this Ligand-Target Pair
TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University of KwaZulu-Natal
Curated by ChEMBL
University of KwaZulu-Natal
Curated by ChEMBL
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of Escherichia coli beta-glucuronidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9.72E+4nMAssay Description:Inhibition of rat liver beta-glucuronidaseMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL
H. Lee Moffitt Cancer Center and Research Institute
Curated by ChEMBL