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SMILES Cn1nc(nc1C1(CC1)c1ccccc1)-c1cnc(N)c(n1)-c1ccc(C(N)=O)c(F)c1

InChI Key InChIKey=YPTMZNNBDPEMOK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50234169   

LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of full length GST-tagged recombinant human DYRK1A expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
TargetCasein kinase I isoform gamma-3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of full length GST-tagged recombinant human CSNK1G3 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal His-tagged truncated recombinant human ECE1 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8W6SPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of PI3Kdelta-mediated AKT phosphorylation at ser473 residue in human JeKo1 cells preincubated for 60 mins followed by anti-IgM stimulation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of full length GST-tagged recombinant human DYRK1B expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234169(CHEMBL4101902)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TF00MMPubMed