null
SMILES CN(Cc1ccc2nccnc2c1)C(=O)c1ccc(cc1)N(Cc1ccccc1)C(=O)c1ccc(O)cc1O
InChI Key InChIKey=ZFKNKAYLMPNXQG-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50236516
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of fluorescein-labelled VER160364 binding to PDHK1 (unknown origin) after 90 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.02E+3nMAssay Description:Displacement of fluorescein-labelled VER160364 from HSP90A (unknown origin) after 90 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of PDHK1 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataKd: 1nMAssay Description:Binding affinity to PDHK1 (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.65E+3nMAssay Description:Binding affinity towards human Dopamine receptor D2 (long) by [3H]-spiperone displacement.More data for this Ligand-Target Pair