null

SMILES COC[C@@H]1CC(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12

InChI Key InChIKey=XVWKFNYNNZFHOB-SMDDNHRTSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239494   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)copy SMILEScopy InChI
Affinity DataIC50: 373nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5W42PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5W42PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)copy SMILEScopy InChI
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D308N
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H9988PUS Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FT8PC5US Patent