null
SMILES COc1ncc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1
InChI Key InChIKey=MEFSUICXZJQPFL-QPJJXVBHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50241871
Affinity DataIC50: 8.10nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...More data for this Ligand-Target Pair