null

SMILES NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1ccc(F)cc1

InChI Key InChIKey=OCLKNWCGOVQNMO-LBPRGKRZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50242824   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242824((S)-1-(5-(4-fluorophenyl)-3-(piperidin-3-ylcarbamo...)copy SMILEScopy InChI
Affinity DataEC50:  600nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242824((S)-1-(5-(4-fluorophenyl)-3-(piperidin-3-ylcarbamo...)copy SMILEScopy InChI
Affinity DataEC50:  30nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check pointMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed
TargetCyclin-dependent kinase 2-associated protein 1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50242824((S)-1-(5-(4-fluorophenyl)-3-(piperidin-3-ylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J102Z9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242824((S)-1-(5-(4-fluorophenyl)-3-(piperidin-3-ylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J102Z9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242824((S)-1-(5-(4-fluorophenyl)-3-(piperidin-3-ylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed