null

SMILES NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1cccc(Cl)c1

InChI Key InChIKey=PZPQGJALDKOXRC-LBPRGKRZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50242893   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242893(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-chlorophen...)copy SMILEScopy InChI
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242893(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-chlorophen...)copy SMILEScopy InChI
Affinity DataEC50:  40nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of campothecin induced check pointMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed
TargetCyclin-dependent kinase 2-associated protein 1(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50242893(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J102Z9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242893(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J102Z9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50242893(1-(3-((S)-piperidin-3-ylcarbamoyl)-5-(3-chlorophen...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PR6PubMed