null

SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@H](CC1)c1ccc(cc1)C#N)C(F)(F)F

InChI Key InChIKey=XRRFWTVWZPSRQE-JTJYXVOQSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50243635   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 0.760nMAssay Description:Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z8SPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 161nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CSZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CSZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CSZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CSZPubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50243635((S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84CSZPubMed