null

SMILES CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4cccc5NC(=O)Cn(c45)c3=O)cc2C1

InChI Key InChIKey=ZAMUDFHSMUEORA-HSZRJFAPSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246422   

TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7TTFPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765FFZPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765FFZPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765FFZPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7TTFPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7TTFPubMed