null

SMILES CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=FOLVOXAEHBGIDM-NTCAYCPXSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50248570   

TargetHistone deacetylase 4(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataKi:  39nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN98P2US Patent
TargetHistone H3.1(Homo sapiens (Human))
MEI PHARMA, INC.

US Patent
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataEC50:  1.10E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0J7FUS Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
MEI PHARMA, INC.

US Patent
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0J7FUS Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0J7FUS Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RD6PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8KX3PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
MEI PHARMA, INC.

US Patent
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 353nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PN98P2US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
MEI PHARMA, INC.

US Patent
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ64P8US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
S*BIO Pte Ltd.

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BZ64P8US Patent