null

SMILES CNC(=O)c1c[nH]c2c(nc(cc12)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F)C(C)C

InChI Key InChIKey=IQJHFWBVPBSSGR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50250892   

TargetBromodomain-containing protein 3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataKd:  8.70E+3nMAssay Description:Binding affinity to human BRD3 bromodomain 2 (G306 to P416) expressed in bacterial cells by BromoScan assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human BRD9 (R130 to V259) expressed in bacterial cells by BromoScan assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BC42Q8US Patent
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataKd:  7.60E+3nMAssay Description:Binding affinity to human TRIM24 (G862 to E980) expressed in bacterial cells by BromoScan assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataEC50:  53nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7KP0US Patent
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)copy SMILEScopy InChI
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to human BRD7 (L125 to R254) expressed in mammalian cells by BromoScan assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7R65PubMed