null

SMILES COc1cc(ccc1Nc1nccc(n1)-c1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1c(F)cccc1F)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=HMXWMMRCKSDFCV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50256478   

TargetInsulin receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataKi:  2.20nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataKi:  5.20nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetAurora kinase B(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of human IGF1R autophosphorylation in transfected mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetAurora kinase A(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetInsulin receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J8MPubMed