null

SMILES Nc1ncnc2n(nc(C#C)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=XXFDMGXYEIKFNZ-SNVBAGLBSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50258966   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3GS9PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3GS9PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 960nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3GS9PubMed
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JM2PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 693nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JM2PubMed