null
SMILES C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1
InChI Key InChIKey=MCBPNFWHHNJTGN-LLVKDONJSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50259376
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of CK1-gamma1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 4.05E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human recombinant MK2More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2WW7HK4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2WW7HK4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKKalpha (unknown origin)More data for this Ligand-Target Pair