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SMILES [2H]C1([2H])OC(N)=N[C@]11c2cc(ccc2C[C@@]11CC[C@@H](CC1)OC)-c1cncnc1

InChI Key InChIKey=HCULHXVLYCNDEI-QKRXBBJISA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264181   

TargetBeta-secretase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50264181(CHEMBL4065448)copy SMILEScopy InChI
Affinity DataKi:  134nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3HVXPubMed
TargetBeta-secretase 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50264181(CHEMBL4065448)copy SMILEScopy InChI
Affinity DataKi:  2.08E+3nMAssay Description:Inhibition of human BACE2 (1 to 473 residues) fused with Fc domain of IgG1 expressed in HEK293 cells preincubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3HVXPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50264181(CHEMBL4065448)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells assessed as decrease in sAPP-beta release after 16 to 17 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3HVXPubMed