null

SMILES Clc1ccc(Cc2nnc(N3CCN(CC3)c3ccc(cn3)C#N)c3ccccc23)cc1

InChI Key InChIKey=HZYOJTRPVYPKHR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50268494   

TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268494(6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 498nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN73T7PubMed