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SMILES COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC

InChI Key InChIKey=JTROLECZHRVLFM-JTQLQIEISA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50272569   

LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Inhibition of full length recombinant human PDE1B1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 142nMAssay Description:Inhibition of bovine retina PDE6A using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of full length recombinant human PDE8B using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of full length recombinant human PDE9A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 409nMAssay Description:Inhibition of full length recombinant human PDE10A1 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of full length recombinant human PDE11A4 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of full length recombinant human PDE1C using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of full length recombinant human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of full length recombinant human PDE4D3 using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of full length recombinant human PDE5A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of full length recombinant human PDE7B using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed
LigandPNGBDBM50272569(CHEMBL4128481)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of full length recombinant human PDE1A using 3',5'-[3H]cAMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KDQPubMed