null

SMILES CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

InChI Key InChIKey=IFIUFCJFLGCQPH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50277784   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75HXCPubMed
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75HXCPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human recombinant PDE7A1 expressed in baculovirus-infected insect Sf9 cells by modified two-step methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79B9BPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZS2XJBPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD1496PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD1496PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase AssayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB19K7PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase AssayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB19K7PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of human recombinant PDE7A using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4P6FPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9H3QPubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at rat P2X7 receptor transfected in HEK cells assessed as inhibition of benzylATP-induced changes in plasma membrane pore formati...More data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
In DepthDetails
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75HXCPubMed