null

SMILES COCCN1CCN(CC1)c1cc(Nc2ncc(C)c(Nc3cccc(CO)c3)n2)cc(c1)S(C)(=O)=O

InChI Key InChIKey=GEEZPWHGYMXIJE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50288441   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288441(CHEMBL4166565)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PP4PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288441(CHEMBL4166565)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of recombinant human JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PP4PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288441(CHEMBL4166565)copy SMILEScopy InChI
Affinity DataEC50:  189nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PP4PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288441(CHEMBL4166565)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PP4PubMed