null

SMILES CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4C[C@@]5(Cc4c3)C(=O)Nc3ncccc53)c3cccc1c23

InChI Key InChIKey=BXLDLKVUVUTHPO-WRHNGFHOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296788   

TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296788(2-((S)-5-methyl-4-oxo-2a,3,4,5-tetrahydropyrrolo[4...)copy SMILEScopy InChI
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MJHPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296788(2-((S)-5-methyl-4-oxo-2a,3,4,5-tetrahydropyrrolo[4...)copy SMILEScopy InChI
Affinity DataIC50: 530nMAssay Description:Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MJHPubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50296788(2-((S)-5-methyl-4-oxo-2a,3,4,5-tetrahydropyrrolo[4...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3MJHPubMed