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SMILES Cc1c(Cc2ccc3ccccc3n2)c2cc(F)ccc2n1CC(O)=O

InChI Key InChIKey=FATGTHLOZSXOBC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50296977   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Antagonistic activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced calcium mobilization after 60 mins by Fluo-3 based fluores...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preinc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XSQPubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMAssay Description:Displacement of [3H]PGD2 from prostaglandin D1 receptor in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]SQ-29548 from thromboxane receptor in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 5.79E+4nMAssay Description:Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced antiapoptotic activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced IL13 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataEC50:  24nMAssay Description:Antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape changeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Inhibition of rat aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of CRTH2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0398RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albuminMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen Ltd.

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KHBPubMed