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SMILES CCCN(CC1CC1)c1cc(ncn1)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=HAKUBDUVAGUCGC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50313311   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  13nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H993ZKUS Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  416nMpH: 7.4 T: 2°CAssay Description:Measurements of 35S-GTPgammaS Binding: Membranes (1 to 10 µg protein) prepared as described above, were incubated in 96-well Scintiplates (PerkinElm...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H993ZKUS Patent
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Merck Serono SA

Curated by ChEMBL
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  142nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SQKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  13nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SQKPubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  416nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SQKPubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
MERCK SERONO SA

US Patent
LigandPNGBDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)copy SMILEScopy InChI
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in human U20S cells assessed as receptor internalization by green fluorescent protein reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38SQKPubMed