null
SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccc(F)cc3F)c2n(C)c1=O)C(=O)NC1CC1
InChI Key InChIKey=XQRUWZMHPKNIDA-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50314780
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataKd: 0.300nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataKd: 1.30E+4nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataKd: 4.00E+4nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia
Curated by ChEMBL
University of Perugia
Curated by ChEMBL
Affinity DataKd: 0.310nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.00E+4nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair