null

SMILES Cc1ccc(cc1-c1cc2cnn(-c3ccc(F)cc3F)c2n(C)c1=O)C(=O)NC1CC1

InChI Key InChIKey=XQRUWZMHPKNIDA-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50314780   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKd:  0.300nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79MDPubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79MDPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79MDPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKd:  0.310nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)copy SMILEScopy InChI
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX79MDPubMed