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SMILES COCCOc1cc2nccc(Nc3cccc(c3)C#C)c2cc1OCCOC

InChI Key InChIKey=ZQYQKUIFZATHRG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314990   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43T7NPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataKd:  390nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50314990(CHEMBL1089203 | N-(3-Ethynylphenyl)-6,7-bis(2-meth...)copy SMILEScopy InChI
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4NVJPubMed