null

SMILES Fc1ccc(cc1)C(Cl)Cn1ncc2c(Nc3cccc(F)c3)ncnc12

InChI Key InChIKey=AAMZEJILAVQVEW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50320700   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q240F5PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q240F5PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  700nMAssay Description:Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q240F5PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  732nMAssay Description:Binding affinity to recombinant wild type human Abl using abitide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5P63PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  750nMAssay Description:Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q240F5PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Institute of Molecular Genetics IGM-CNR

Curated by ChEMBL
LigandPNGBDBM50320700(1-[2-chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluoroph...)copy SMILEScopy InChI
Affinity DataKi:  3.00E+3nMAssay Description:Mixed-type inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q240F5PubMed