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SMILES CN(C)CCCOc1ccc(cc1C(F)(F)F)-c1cc2n(C)cnc2c(n1)C#N

InChI Key InChIKey=CZLJABZJYZVKFX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50323247   

TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3CTTUS Patent
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of lip10 by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetCathepsin S(Mus musculus (Mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of mouse cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RR9PubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:Inhibition of cathepsin S-mediated proteolytic cleavage of MHC2 associated invariant chain in human JY cells assessed as accumulation of lip10 by Wes...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RR9PubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 776nMAssay Description:Inhibition of human cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RR9PubMed
TargetCathepsin B(Homo sapiens (Human))
Merck Research laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetCathepsin L2(Homo sapiens (Human))
Merck Research laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin VMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetProcathepsin L(Homo sapiens (Human))
Merck Research laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 776nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2P85PubMed
TargetCathepsin S(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of human cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RR9PubMed