null

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C

InChI Key InChIKey=FFNIWOOLZGAOAB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50326198   

TargetAurora kinase B(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataEC50: >1.20E+3nMAssay Description:Inhibition of aurora B in human HeLa cells assessed as increase of >= 4N DNA level after 24 hrs by Hoechst stainingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CDK5 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 385nMAssay Description:Inhibition of LCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 503nMAssay Description:Inhibition of Abl by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:Inhibition of Tie-2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of c-Kit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of c-Fms by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 5.75E+3nMAssay Description:Inhibition of Src by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of P38alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of EphB4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of IGFR1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Zap70 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Jak2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Jak3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of BTK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of JNK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of p70s6k by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PLK1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Erk1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PKBalpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C829H0PubMed