null
SMILES COc1cc(ccc1Nc1ncc2NC(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
InChI Key InChIKey=LGLHCXISMKHLIK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50337126
Affinity DataKd: 15nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute, Inc.
US Patent
Dana-Farber Cancer Institute, Inc.
US Patent
Affinity DataKd: 670nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute, Inc.
US Patent
Dana-Farber Cancer Institute, Inc.
US Patent
Affinity DataKd: >670nMAssay Description:Binding affinity to ERK5 by immobilized ligand displacement assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase DCLK1(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In DepthDetails
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Dana-Farber Cancer Institute, Inc.
US Patent
Dana-Farber Cancer Institute, Inc.
US Patent
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5 autophosphorylation pretreated for 1 hr followed by EGF stimulation ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by AlphaScreen displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Focal adhesion kinase (unknown origin) using Tyr 07 peptide substrate incubated for 60 mins at room temperature followed by 60 mins dev...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of tracer 236 binding to recombinant human GST-tagged TNK2 catalytic domain (110 to 476 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair