null

SMILES CNC(C)C1(CCCCC1)c1ccc2ccccc2c1

InChI Key InChIKey=WISXSHNMYCUZHH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50337912   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]dopamine reuptake at human human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming gene 1 protein(Homo sapiens)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming 1(Rat)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming gene 1 protein(Homo sapiens)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 468nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 145nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming 1(Rat)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming gene 1 protein(Homo sapiens)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming 1(Rat)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Quantification of dopamine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat striatum. The uptake of...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 118nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming gene 1 protein(Homo sapiens)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 341nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 176nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Quantification of 5-HT uptake was performed using synaptosomes isolated in a 0.32M sucrose buffer from a male Wistar rat cortex. The uptake of radiol...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetNeuroepithelial cell-transforming 1(Rat)
SUNOVION PHARAMCEUTICALS INC.

US Patent
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Quantification of norepinephrine uptake was performed using synaptosomes isolated in a 0.32 M sucrose buffer from a male Wistar rat hypothalamus. The...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP77BXUS Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sunovion Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50337912(CHEMBL1684056 | N-methyl-1-(1-(naphthalen-2-yl)cyc...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CV4J2PPubMed