null

SMILES NCc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(c1)C(F)(F)F

InChI Key InChIKey=USXXPFFCBBHACO-IBGZPJMESA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339613   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed