null

SMILES CCc1c(C)nc2ncnn2c1Nc1ccc(cc1)C(C)C

InChI Key InChIKey=HSKDDEMAAZUZGH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345437   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MMV MEDICINES FOR MALARIA VENTURE; UNIVERSITY OF WASHINGTON

US Patent
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)copy SMILEScopy InChI
Affinity DataIC50: 1.66E+3nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D79954US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of His6-tagged recombinant human dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as substrate after 10 t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN16HSPubMed